X-ray microscopy and tomography detect the accumulation of bare and PEG-coated gold nanoparticles in normal and tumor mouse tissues

C. C. Chien, Chang-Chieh Cheng, H. H. Chen, Y. Hwu*, Y. S. Chu, C. Petibois, A. Chen, Yu-Tai Ching, G. Margaritondo

*Corresponding author for this work

研究成果: Article同行評審

9 引文 斯高帕斯(Scopus)

摘要

We demonstrate that, with appropriate staining, high-resolution X-ray microscopy can image complicated tissue structures-cerebellum and liver-and resolve large or small amounts of Au nanoparticles in these tissues. Specifically, images of tumor tissue reveal high concentrations of accumulated Au nanoparticles. PEG (poly(ethylene glycol)) coating is quite effective in enhancing this accumulation and significantly modifies the mechanism of uptake by reticuloendothelial system (RES) organs.

原文English
頁(從 - 到)1287-1296
頁數10
期刊Analytical and Bioanalytical Chemistry
404
發行號5
DOIs
出版狀態Published - 1 九月 2012

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