Total synthesis of a glycoglycerolipid from Meiothermus taiwanensis through a one-pot glycosylation reaction and exploration of its immunological properties

Bhaswati Ghosh, Yen Hsun Lai, Yu Yin Shih, Tapan Kumar Pradhan, Chun Hung Lin*, Kwok-Kong Mong

*Corresponding author for this work

研究成果: Article同行評審

8 引文 斯高帕斯(Scopus)

摘要

The total synthesis of a glycoglycerolipid isolate of Meiothermus taiwanensis and its truncated structural analogues is reported. Our synthesis employed DMF-modulated and low-concentration glycosylation reactions for the construction of α- and β-glycosidic bonds in the absence of participating protecting groups. Further simplification of the synthesis was achieved by employing a low-concentration one-pot glycosylation procedure. Preliminary immunological studies showed that one of the truncated structural analogues suppressed the cytokine production of THP-1 monocytes.

原文English
頁(從 - 到)3191-3199
頁數9
期刊Chemistry - An Asian Journal
8
發行號12
DOIs
出版狀態Published - 1 十二月 2013

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