Soluble polymer-supported synthesis of benzodiazepinones

Cheng Yi Wu, Chung-Ming Sun*

*Corresponding author for this work

研究成果: Article同行評審

6 引文 斯高帕斯(Scopus)

摘要

Soluble polymer-supported synthetic method provides a highly efficient route for the construction of biologically important 1,5-benzodiazepin-2-ones. A library of N-substituted benzodiazepinones can be readily assembled utilizing SNAr reaction, reduction of nitro group and one-pot cyclization following N-alkylation as the key step in the synthesis. All reactions in the sequence were performed at room temperature to facilitate the generation of libraries in a parallel fashion. The crude products were obtained in 80-95% yield with 60-96% HPLC purity.

原文English
頁(從 - 到)959-962
頁數4
期刊Bioorganic and Medicinal Chemistry Letters
12
發行號6
DOIs
出版狀態Published - 25 三月 2002

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