Soluble polymer-supported synthesis of arylpiperazines

Pi Chi Pan, Chung-Ming Sun*

*Corresponding author for this work

研究成果: Article同行評審

34 引文 斯高帕斯(Scopus)

摘要

A method for soluble, inexpensive polymer-supported synthesis of piperazine and piperidine libraries on the basis of nucleophilic aryl substitution (S(N)Ar) and N-acylation is reported. Asymmetric N, N'- disubstituted piperazine and piperidine derivatives, that are potential drug candidates, can be synthesized in quantitative yields and excellent purity after several steps by simple precipitation and washing. This liquid phase method should prove to be a useful tool for constructing combinatorial libraries coataining diamine moiety.

原文English
頁(從 - 到)9505-9508
頁數4
期刊Tetrahedron Letters
39
發行號51
DOIs
出版狀態Published - 17 十二月 1998

指紋 深入研究「Soluble polymer-supported synthesis of arylpiperazines」主題。共同形成了獨特的指紋。

引用此