Soluble polymer-supported synthesis of 2-(arylamino)benzimidazoles

Cheng Yi Wu, Chung-Ming Sun*

*Corresponding author for this work

研究成果: Article同行評審

14 引文 斯高帕斯(Scopus)

摘要

A novel liquid-phase method for the construction of biologically important benzimidazoles has been developed. A library of N-substituted 2-aminobenzimidazoles was readily assembled utilizing SNAr reactions, reduction of the nitro group and a one-pot cyclization with isothiocyanate as the key step in the synthesis. The crude benzimidazoles were obtained in 80-99% yields with 78-95% HPLC purity.

原文English
頁(從 - 到)1529-1533
頁數5
期刊Tetrahedron Letters
43
發行號8
DOIs
出版狀態Published - 18 二月 2002

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