Sample Preparation on Micro-Electrode-Dot-Array Digital Microfluidic Biochips

Zipeng Li, Kelvin Yi Tse Lai, Krishnendu Chakrabarty, Tsung Yi Ho, Chen-Yi Lee

研究成果: Conference contribution同行評審

13 引文 斯高帕斯(Scopus)

摘要

Sample preparation in digital microfluidics refers to the generation of droplets with target concentrations for onchip biochemical applications. In recent years, digital microfluidic biochips (DMFBs) have been adopted as a platform for sample preparation. However, there remain one major problem associated with sample preparation on a conventional DMFB. For conventional DMFBs, only a (1:1) mixing/splitting model can be used, leading to an increase in the number of fluidic operations required for sample preparation. To overcome the drawback, we adopt a next generation DMFB platform, referred to as micro-electrode-dot-array (MEDA), for sample preparation. We propose the first sample preparation method that exploits the MEDA-specific advantages of fine-grained control of droplet sizes and real-time droplet sensing. Experimental demonstration using a fabricated MEDA biochip and simulation results highlight the effectiveness of the proposed sample-preparation method.

原文English
主出版物標題Proceedings - 2017 IEEE Computer Society Annual Symposium on VLSI, ISVLSI 2017
編輯Ricardo Reis, Mircea Stan, Michael Huebner, Nikolaos Voros
發行者IEEE Computer Society
頁面146-151
頁數6
ISBN(電子)9781509067626
DOIs
出版狀態Published - 20 七月 2017
事件2017 IEEE Computer Society Annual Symposium on VLSI, ISVLSI 2017 - Bochum, North Rhine-Westfalia, Germany
持續時間: 3 七月 20175 七月 2017

出版系列

名字Proceedings of IEEE Computer Society Annual Symposium on VLSI, ISVLSI
2017-July
ISSN(列印)2159-3469
ISSN(電子)2159-3477

Conference

Conference2017 IEEE Computer Society Annual Symposium on VLSI, ISVLSI 2017
國家Germany
城市Bochum, North Rhine-Westfalia
期間3/07/175/07/17

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