Ruthenium hydride catalyzed regioselective addition of aldehydes to enones to give 1,3-diketones

Takahide Fukuyama*, Takashi Doi, Satoshi Minamino, Sohei Omura, Ilhyong Ryu

*Corresponding author for this work

研究成果: Article

57 引文 斯高帕斯(Scopus)

摘要

(Chemical Equation Presented) It all adds up: Straightforward access to 2-alkyl-substituted 1,3-diketones is provided by a regioselective addition of aldehydes to enones catalyzed by the ruthenium hydride catalyst [RuHCl(CO)(PPh3)3] (see scheme). The reaction involves a hydrometalation of the enone to form a metal enolate, a cross-aldol reaction to form an alkoxymetal species, and a subsequent β-metal hydride elimination.

原文English
頁(從 - 到)5559-5561
頁數3
期刊Angewandte Chemie - International Edition
46
發行號29
DOIs
出版狀態Published - 1 八月 2007

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