Role of angiogenic and non-angiogenic mechanisms in oral squamous cell carcinoma: Correlation with histologic differentiation and tumor progression

Yi Shing Shieh, Herng Sheng Lee, Shine Gwo Shiah, Yi Wen Chu, Cheng-Wen Wu Lee, Long Chang Chang*

*Corresponding author for this work

研究成果: Article同行評審

41 引文 斯高帕斯(Scopus)

摘要

BACKGROUND: Angiogenesis has been demonstrated to associate with various measures of tumor aggressiveness in many human malignancies. However, studies of tumor angiogenesis in oral squamous cell carcinoma (SCC) are still unclear. Recent studies indicate non-angiogenesis mechanism (tumor-lined vessel) may exist in certain tumors. Therefore, we investigate microvessel density (MVD) and tumor-lined vessel in oral SCC. METHODS: Peritumoral and intratumoral MVD were measured by immunohistochemical staining. Tumor-lined vessels were identified by double staining. Statistical analysis of peritumoral and intratumoral MVD and presence of tumor-lined vessels with clinicopathologic parameters was performed. RESULTS: The results showed peritumoral MVD increased with disease progression and further increases of intratumoral MVD was detected by CD31 and CD34. Non-angiogenesis, tumor-lined vessel, presented in oral SCC and correlated significantly with tumor size, stage, and histologic differentiation. CONCLUSION: Our results suggest at the initiation of oral SCC, increasing vascularity is observed at the periphery of the tumor. As the tumor continues to grow, further increases of intratumoral vascularity and the presence of tumor-lined vessels are associated with cancer progression.

原文English
頁(從 - 到)601-606
頁數6
期刊Journal of Oral Pathology and Medicine
33
發行號10
DOIs
出版狀態Published - 1 十一月 2004

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