Regioselective radical bromoallylation of allenes leading to 2-bromo-substituted 1,5-dienes

Takashi Kippo, Takahide Fukuyama, Ilhyong Ryu*

*Corresponding author for this work

研究成果: Article同行評審

35 引文 斯高帕斯(Scopus)

摘要

The regioselective radical bromoallylation of allenes proceeded efficiently in the presence of AIBN as a radical initiator to give 2-bromo-substituted 1,5-dienes in excellent yields. The addition of a bromine radical took place regioselectively onto the central carbon of allenes generating a stable allyl radical, which underwent addition/β-fragmentation reactions with allylbromides. The products could be further functionalized by Pd-catalyzed coupling reactions.

原文English
頁(從 - 到)3864-3867
頁數4
期刊Organic Letters
13
發行號15
DOIs
出版狀態Published - 5 八月 2011

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