Predicting protein crystallization using a simple scoring card method

Watshara Shoombuatong, Hui Ling Huang, Jeerayut Chaijaruwanich, Phasit Charoenkwan, Hua Chin Lee, Shinn-Ying Ho

研究成果: Conference contribution同行評審

9 引文 斯高帕斯(Scopus)

摘要

Many computational methods have been developed to predict protein crystallization. Most methods use amino acid and dipeptide compositions as part of the informative features. To advance the prediction accuracy, the support vector machine (SVM) based classifiers and ensemble approaches were effective and commonly-used techniques. However, these techniques suffer from the low interpretation ability of insight into crystallization. In this study, we utilize a newly-developed scoring card method (SCM) with a dipeptide composition feature to predict protein crystallization. This SCM classifier obtains prediction results 74%, 0.55 and 0.83 for accuracy, sensitivity and specificity, respectively, which is comparable to the SVM classifier using the same benchmarks. The experimental results show that the SCM classifier has advantages of simplicity, high interpretability, and high accuracy in predicting protein crystallization, compared with existing SVM-basedensemble classifiers.

原文English
主出版物標題Proceedings of the IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB 2013 - 2013 IEEE Symposium Series on Computational Intelligence, SSCI 2013
頁面23-30
頁數8
DOIs
出版狀態Published - 10 十月 2013
事件10th Annual IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB 2013 - 2013 IEEE Symposium Series on Computational Intelligence, SSCI 2013 - Singapore, Singapore
持續時間: 16 四月 201319 四月 2013

出版系列

名字Proceedings of the IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB 2013 - 2013 IEEE Symposium Series on Computational Intelligence, SSCI 2013

Conference

Conference10th Annual IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB 2013 - 2013 IEEE Symposium Series on Computational Intelligence, SSCI 2013
國家Singapore
城市Singapore
期間16/04/1319/04/13

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