Plasma deactivation of endotoxic biomolecules: Vacuum ultraviolet photon and radical beam effects on lipid A

Ting Ying Chung, Ning Ning, Jhih-Wei Chu, David B. Graves*, Elliot Bartis, Seog Joonil Seog, Gottlieb S. Oehrlein

*Corresponding author for this work

研究成果: Article

21 引文 斯高帕斯(Scopus)

摘要

It is widely accepted that plasma-generated energetic and reactive species are responsible for plasma-induced sterilization; however, how these species act alone or synergistically to deactivate endotoxic biomolecules is not completely understood. Using a vacuum beam system, we study the effects of vacuum ultraviolet (VUV) radiation, oxygen and deuterium radicals on lipid A, the immune-stimulating region of lipopolysaccharide. VUV-induced photolysis causes bulk modification of exposed lipid A film up to the penetration depth of VUV photons, ≈200 nm. Although radical-induced etch yield of lipid A is lower than VUV-induced photolysis, secondary ion mass spectrometry and human whole blood-based assay suggest that radicals render a higher degree of modification at the film surface. This study contributes to the fundamental understanding of plasma effects on biomolecules for a better deactivation scheme and applications.

原文English
頁(從 - 到)167-180
頁數14
期刊Plasma Processes and Polymers
10
發行號2
DOIs
出版狀態Published - 1 二月 2013

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