Optical biosensors based on four different surface plasmon resonance modes: Sensitivity comparison

F. C. Chien*, Shean-Jen Chen

*Corresponding author for this work

研究成果: Conference article同行評審

2 引文 斯高帕斯(Scopus)

摘要

Current surface plasmon resonance (SPR) modes based on the attenuated total reflection (ATR) method can broadly be categorized as: conventional SPR, long-range SPR (LRSPR), coupled plasmon-waveguide resonance (CPWR), and waveguide-coupled SPR (WCSPR). Although the features of optical biosensors are dependent upon their particular SPR mode, a common requirement for all biosensors utilized for biomolecular interaction analysis (BIA) is a high degree of sensitivity. The current paper presents a theoretical analysis and comparison of the sensitivity and resolution of these four types of SPR biosensors when employed in three of the most prevalent detection methods, namely angular interrogation, wavelength interrogation, and intensity measurement. This study develops a detailed understanding of the influences of various biosensor design parameters in order to enhance the sensitivity and detection limit capabilities of such devices.

原文English
頁(從 - 到)148-159
頁數12
期刊Proceedings of SPIE - The International Society for Optical Engineering
5327
DOIs
出版狀態Published - 16 十一月 2004
事件Plasmonics in Biology and Medicine - San Jose, CA, United States
持續時間: 26 一月 200427 一月 2004

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