Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles

Wen Lo, Ara Ghazaryan, Chien Hsin Tso, Po-Sheng Hu, Wei Liang Chen, Tsung Rong Kuo, Sung Jan Lin, Shean-Jen Chen, Chia Chun Chen*, Chen Yuan Dong

*Corresponding author for this work

研究成果: Article

3 引文 斯高帕斯(Scopus)

摘要

Transdermal delivery of nanocarriers provides an alternative pathway to transport therapeutic agents, alleviating pain, improving compliance of patients, and increasing overall effectiveness of delivery. In this work, enhancement of transdermal delivery of fluorescent nanoparticles and sulforhodamine B with assistance of oleic acid was visualized utilizing multiphoton microscopy (MPM) and analyzed quantitatively using multi-photon excitation-induced fluorescent signals. Results of MPM imaging and MPM intensity-based spatial depth-dependent analysis showed that oleic acid is effective in facilitating transdermal delivery of nanoparticles.

原文English
文章編號213701
期刊Applied Physics Letters
100
發行號21
DOIs
出版狀態Published - 21 五月 2012

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    Lo, W., Ghazaryan, A., Tso, C. H., Hu, P-S., Chen, W. L., Kuo, T. R., Lin, S. J., Chen, S-J., Chen, C. C., & Dong, C. Y. (2012). Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles. Applied Physics Letters, 100(21), [213701]. https://doi.org/10.1063/1.3701135