Multiplex microsphere-based flow cytometric platforms for protein analysis and their application in clinical proteomics - From assays to results

Hsin-Yun Hsu*, Thomas O. Joos, Hisashi Koga

*Corresponding author for this work

研究成果: Article同行評審

49 引文 斯高帕斯(Scopus)

摘要

Advances in high-throughput screening, together with rapid progress in genomic and proteomic sciences, have considerably stimulated the development of a variety of biomarker discovery tools and have contributed to the improvement of clinical diagnosis. Major challenges include the obtaining of high-quality data sets based on assays that are rapid, reliable, and inexpensive, but still highly sensitive and easy to perform. The microsphere-based flow cytometric technology is a platform that is currently entering the diagnostic market. This article reviews the development and the applications of microsphere-based flow cytometric platforms in basic and applied proteomic research, and discusses bead-based assays used in clinical applications.

原文English
頁(從 - 到)4008-4019
頁數12
期刊Electrophoresis
30
發行號23
DOIs
出版狀態Published - 1 十二月 2009

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