Miniaturized cortex cooling device and system for hypothermia therapy application on freely moving rat

Chih Wei Chang*, Kuan Chou Hou, Lei Chun Chou, Jin-Chern Chiou, Jeng-Ren Duann, Yun Wen Tsai

*Corresponding author for this work

研究成果: Conference contribution

摘要

This paper presents a miniaturized brain cortex cooling device and system using thermoelectric (TE) cooler for hypothermia therapy application on freely moving rat. Two type of cooling electrodes including planar and micro-needle structures are fabricated and studied by EEG recording. Comparing to prior arts, our approach can be applied under freely moving behavior. The cooling temperature is designed as 2°C to avoid permanent injury in brain. Packaged planar or needle electrode with TE cooler consumes only 2×2mm2. EEG recording electrodes and thermocouple are implanted for observation as well. Simulation result shows that TE-cooler with needle type electrode behaves deeper effective cooling depth and faster cooling response in rodent cortex range (∼2mm deep). Long term EEG monitoring on freely moving rat also presents no extra side effects with continuously cooling.

原文English
主出版物標題IEEE SENSORS 2012 - Proceedings
DOIs
出版狀態Published - 1 十二月 2012
事件11th IEEE SENSORS 2012 Conference - Taipei, Taiwan
持續時間: 28 十月 201231 十月 2012

出版系列

名字Proceedings of IEEE Sensors

Conference

Conference11th IEEE SENSORS 2012 Conference
國家Taiwan
城市Taipei
期間28/10/1231/10/12

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  • 引用此

    Chang, C. W., Hou, K. C., Chou, L. C., Chiou, J-C., Duann, J-R., & Tsai, Y. W. (2012). Miniaturized cortex cooling device and system for hypothermia therapy application on freely moving rat. 於 IEEE SENSORS 2012 - Proceedings [6411273] (Proceedings of IEEE Sensors). https://doi.org/10.1109/ICSENS.2012.6411273