Micro-channel fabrication by femtosecond laser to arrange neuronal cells on multi-electrode arrays

Chie Hosokawa*, Suguru N. Kudoh, Mariko Suzuki, Ai Kiyohara, Yoichiroh Hosokawa, Kazunori Okano, Hiroshi Masuhara, Takahisa Taguchi

*Corresponding author for this work

研究成果: Article同行評審

10 引文 斯高帕斯(Scopus)

摘要

We propose and demonstrate micro-channel fabrication by femtosecond-laser processing to arrange neuronal cells on multi-electrode arrays (MEAs). When neuronal cells were seeded in the micro-channels on MEAs, they elongated their neurites along the channel and finally formed the network patterned on MEAs. The spontaneous electrical activity of the neuronal networks on MEAs was evaluated by using electrophysiological systems, indicating that patterned network was functionally activated along the channels. The present method is applicable to analyze network dynamics of living neuronal cells patterned artificially.

原文English
頁(從 - 到)423-428
頁數6
期刊Applied Physics A: Materials Science and Processing
101
發行號2
DOIs
出版狀態Published - 1 十一月 2010

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