Metabolic engineering design strategies for increasing acetyl-coa flux

Jason T. Ku, Arvin Y. Chen, Ethan I. Lan*

*Corresponding author for this work

研究成果: Review article同行評審

4 引文 斯高帕斯(Scopus)

摘要

Acetyl-CoA is a key metabolite precursor for the biosynthesis of lipids, polyketides, isoprenoids, amino acids, and numerous other bioproducts which are used in various industries. Metabolic engineering efforts aim to increase carbon flux towards acetyl-CoA in order to achieve higher productivities of its downstream products. In this review, we summarize the strategies that have been implemented for increasing acetyl-CoA flux and concentration, and discuss their effects. Furthermore, recent works have developed synthetic acetyl-CoA biosynthesis routes that achieve higher stoichiometric yield of acetyl-CoA from glycolytic substrates.

原文English
文章編號166
期刊Metabolites
10
發行號4
DOIs
出版狀態Published - 四月 2020

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