Liquid phase synthesis of arylamines and its application to the benzimidazolone via nucleophilic aryl substitution

Pi Chi Pan, Chung-Ming Sun*

*Corresponding author for this work

研究成果: Article同行評審

16 引文 斯高帕斯(Scopus)

摘要

A method for soluble, inexpensive polymer-supported synthesis of aryl amines and benzimidazolone on the basis of nucleophilic aryl substitution (S(N)Ar) is described. This method involves a direct coupling reaction between resin bound aryl fluoride and amines at ambient temperature. The products are isolated in quantitative yields and excellent purity by simple precipitation and washing. This liquid phase method proves to be a useful tool for constructing combinatorial arylamine and benzimidazolone libraries.

原文English
頁(從 - 到)1537-1540
頁數4
期刊Bioorganic and Medicinal Chemistry Letters
9
發行號11
DOIs
出版狀態Published - 7 六月 1999

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