The advancement of technology has led to an increasingly permeable boundary between work and off-work time. As such, employees may face pressure to immediately respond to work-related information and communication technology (ICT) messages during off-work time. This study examines the mediating role of workplace telepressure on the relationships between ICT availability demands with burnout and work-family conflict, as well as the moderating effects of self-regulation on these relationships. Data were collected from 185 full-time employees at two time points. Results indicated full support for the moderated mediation model, demonstrating that workplace telepressure mediated the relationships between ICT availability demands and burnout and work-family conflict. Moreover, dispositional self-regulation strengthened the direct effect of ICT availability demands on workplace telepressure and the indirect effects of ICT availability demands on burnout and work-family conflict. Theoretical and practical implications are discussed.