Label-free detection of DNA hybridization using transistors based on CVD grown graphene

Tzu Yin Chen, Phan Thi Kim Loan, Chang Lung Hsu, Yi Hsien Lee, Jacob Tse-Wei Wang, Kung-Hwa Wei, Cheng Te Lin*, Lain Jong Li

*Corresponding author for this work

研究成果: Article同行評審

141 引文 斯高帕斯(Scopus)

摘要

The high transconductance and low noise of graphene-based field-effect transistors based on large-area monolayer graphene produced by chemical vapor deposition are used for label-free electrical detection of DNA hybridization. The gate materials, buffer concentration and surface condition of graphene have been optimized to achieve the DNA detection sensitivity as low as 1pM (10 -12 M), which is more sensitive than the existing report based on few-layer graphene. The graphene films obtained using conventional PMMA-assisted transfer technique exhibits PMMA residues, which degrade the sensing performance of graphene. We have demonstrated that the sensing performance of the graphene samples prepared by gold-transfer is largely enhanced (by 125%).

原文English
頁(從 - 到)103-109
頁數7
期刊Biosensors and Bioelectronics
41
發行號1
DOIs
出版狀態Published - 15 三月 2013

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