Flow Giese reaction using cyanoborohydride as a radical mediator

Takahide Fukuyama, Takuji Kawamoto, Mikako Kobayashi, Ilhyong Ryu*

*Corresponding author for this work

研究成果: Article同行評審

16 引文 斯高帕斯(Scopus)

摘要

Tin-free Giese reactions, employing primary, secondary, and tertiary alkyl iodides as radical precursors, ethyl acrylate as a radical trap, and sodium cyanoborohydride as a radical mediator, were examined in a continuous flow system. With the use of an automated flow microreactor, flow reaction conditions for the Giese reaction were quickly optimized, and it was found that a reaction temperature of 70 °C in combination with a residence time of 10-15 minutes gave good yields of the desired addition products.

原文English
頁(從 - 到)1791-1796
頁數6
期刊Beilstein Journal of Organic Chemistry
9
DOIs
出版狀態Published - 3 九月 2013

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