Exploring a sulfone linker utilizing trimethyl aluminum as a cleavage reagent: Solid-phase synthesis of sulfonamides and ureas

Tsai Wen Chung, Chih Hau Chen, Chu Chung Lin, Hsien Jen Wu, Chung-Ming Sun*, Wen-Sheng Chung

*Corresponding author for this work

研究成果: Article同行評審

2 引文 斯高帕斯(Scopus)

摘要

A novel and efficient cleavage reagent, trimethyl aluminum, for traceless sulfinate-functionalized resin has been developed. The synthesis of sulfonamide and urea derivatives via a traceless solid-phase sulfone linker strategy through six synthetic steps comprising utilization of trimethyl aluminum as a novel cleavage reagent was also established. An insight of the plausible mechanism of the cleavage reaction was discussed.

原文English
頁(從 - 到)463-476
頁數14
期刊Molecular Diversity
16
發行號3
DOIs
出版狀態Published - 1 八月 2012

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