Dye- A nd dye-doped liquid crystals in biosensing

Mon Juan Lee, Yi Lun Chiang, Abhishek Karn, Po Chang Wu, Wei Lee

研究成果: Conference contribution同行評審

2 引文 斯高帕斯(Scopus)

摘要

Liquid crystals (LCs) have been suggested to have a place in biological sensing for detection and quantitation of biomolecules. Through many years, texture observation has long been the core technique in LC-based bioassays. Its principle stems from the texture change of LCs due to the interruption of the initially homeotropic alignment in nematic bulks or the radial-to-bipolar configuration transition in LC droplets in the presence of biomolecules. Biodetection through optical texture observation is convenient but remains a qualitative method, and alternative approaches of detection and quantitative analysis are necessary for the development of a practical LC-based biosensor. In this study, we explore the potential of two dye-enhanced LCs, a dye LC (DLC) and a dye-doped LC (DDLC), in biosensing and protein quantitation. Depending on the chromophore or dye incorporated in DLC and DDLC, the dichroic features of these LCs enable us to analyze the change in their orientation in the presence of biomolecules by transmission spectrometry, from which spectral parameters are derived to establish novel LC-based protein quantitative methods.

原文English
主出版物標題Liquid Crystals XXII
編輯Iam Choon Khoo
發行者SPIE
ISBN(電子)9781510620414
DOIs
出版狀態Published - 1 一月 2018
事件Liquid Crystals XXII 2018 - San Diego, United States
持續時間: 19 八月 201820 八月 2018

出版系列

名字Proceedings of SPIE - The International Society for Optical Engineering
10735
ISSN(列印)0277-786X
ISSN(電子)1996-756X

Conference

ConferenceLiquid Crystals XXII 2018
國家United States
城市San Diego
期間19/08/1820/08/18

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