Differentiation of bacteria cell wall using Raman scattering enhanced by nanoparticle array

T. Y. Liu, Y. Chen, H. H. Wang, Y. L. Huang, Y. C. Chao, K. T. Tsai, W. C. Cheng, C. Y. Chuang, Y. H. Tsai, C. Y. Huang, D. W. Wang, C. H. Lin, J. K. Wang, Y. L. Wang*

*Corresponding author for this work

研究成果: Article同行評審

23 引文 斯高帕斯(Scopus)

摘要

We have fabricated surface-enhanced Raman scattering (SERS) substrates based on arrays of silver nanoparticles grown on porous anodic alumina templates. Using this nanotechnology platform, label-free and high-speed detection of bacteria are achieved. SERS spectra of various bacteria including Staphylococcus Aureus (Gram-positive bacterium), Klebsiella Pneumoniae (Gram-negative bacterium), and Mycobacterium Smegmatis (Mycobacterium) were recorded. The highly reproducible SERS-based technological platform is capable of differentiating different kinds of bacteria by PCA, LDA, clustering analysis, and SVM methods, which provides promising opportunity for biosensing of clinical microbes.

原文English
頁(從 - 到)5004-5008
頁數5
期刊Journal of Nanoscience and Nanotechnology
12
發行號6
DOIs
出版狀態Published - 2012

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