This study presents an organic light-emitting diode (OLED) drive circuit and an organic photo detector (OPD) readout circuits for a vibration sensor. Vibration sensor consist of micro-electro-mechanical systems (MEMS), which are OLED and OPD needs to be integrated for many applications in automation or consumer electronics. The light flux is generated by an OLED located on top of the structure and the modulated light flux is measured by an OPD. The OLED drive circuit contains pulse width modulation (PWM) driver to control PWM output for optimization of voltage operation is designed in order to minimize power consumption efficiency of device. The readout circuit includes a trans-impedance amplifier (TIA) to convert incident light of OPD to voltage output, a 14-bit analog-to-digital converter (ADC) to extract amplitude of vibration level, circuit to generate clock for time-to-digital converter (TDC) which detect frequency of vibration sensor. The designed circuit has been successfully fabricated by using TSMC 0.18 μm CMOS process, the chip area is 1.012 mm 2 . The power consumption of chip is about 6.2 mW. The measured frequency of PWM is about 200 kHz with 50% duty cycle. The frequency range of the vibration can be sensed well as about 10 Hz1.5 kHz, and resulting in high SNR at frequencies under 60 Hz.