CPSARST: An efficient circular permutation search tool applied to the detection of novel protein structural relationships

Wei-Cheng Lo, Ping Chiang Lyu*

*Corresponding author for this work

研究成果: Article同行評審

29 引文 斯高帕斯(Scopus)

摘要

Circular permutation of a protein can be visualized as if the original amino- and carboxyl termini were linked and new ones created elsewhere. It has been well-documented that circular permutants usually retain native structures and biological functions. Here we report CPSARST (Circular Permutation Search Aided by Ramachandran Sequential Transformation) to be an efficient database search tool. In this post-genomics era, when the amount of protein structural data is increasing exponentially, it provides a new way to rapidly detect novel relationships among proteins.

原文English
文章編號R11
期刊Genome Biology
9
發行號1
DOIs
出版狀態Published - 18 一月 2008

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