Computation of brain neurodegeneration in the Alzheimer's fly

P. C. Lee*, Y. R. Huang, H. M. Chang, A. S. Chiang, Yu-Tai Ching

*Corresponding author for this work

研究成果: Conference contribution同行評審

摘要

Expression of human A/342 peptide in the Drosophila brain induces pathological phenotypes resembling Alzheimer's disease (PNAS 101, 6623-6628). Three-dimensional confocal imaging reveals extensive vacuoles caused by neurodegeneration in the brain of aged but not young A β 42 flies. Here, we report a three-dimensional computation algorism allowing semi-automatic measurement of numbers and volumes of brain vacuoles. The method employed matched filters, α -shape, and the active-contour techniques. Using this method, a good result depicting the contours of the vacuoles can be obtained. A more accurate algorithm is still under development. Accurate evaluation of brain pathology in Alzheimer's flies may facilitate the understanding of molecular mechanisms underlying A β. toxicity and the discovery of novel therapeutic targets for Alzheimer's disease.

原文English
主出版物標題Medical Imaging 2006
主出版物子標題Physiology, Function, and Structure from Medical Images
DOIs
出版狀態Published - 30 六月 2006
事件Medical Imaging 2006: Physiology, Function, and Structure from Medical Images - San Diego, CA, United States
持續時間: 12 二月 200614 二月 2006

出版系列

名字Progress in Biomedical Optics and Imaging - Proceedings of SPIE
6143 II
ISSN(列印)1605-7422

Conference

ConferenceMedical Imaging 2006: Physiology, Function, and Structure from Medical Images
國家United States
城市San Diego, CA
期間12/02/0614/02/06

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