Coherent interaction of optical second harmonic generation in collagen fibrils

Shi Wei Chu*, Shih Peng Tai, Ming Che Chan, Chi Kuang Sun, I. Ching Hsiao, Chi Hung Lin, Yung Chih Chen, Bai Ling Lin

*Corresponding author for this work

研究成果: Conference contribution同行評審

摘要

We present the first experimental comparison between optical second harmonic generation images and atomic force microscope images in a matrix of nano-scaled collagen fibrils. Substantial variation of forward and backward propagated second harmonic generation radiation is observed in a single collagen fibril and is nicely correlated with the accurately determined thickness from an atomic force microscope. Contradicting to conventional nonlinear optical theory, our result indicates a linear relationship between fibril thickness and forward / backward second harmonic generation ratio. This is the first demonstration of estimating fibril thickness with nanometer precision by a noninvasive optical method.

原文English
主出版物標題Multiphoton Microscopy in the Biomedical Sciences VIII
DOIs
出版狀態Published - 21 四月 2008
事件Multiphoton Microscopy in the Biomedical Sciences VIII - San Jose, CA, United States
持續時間: 20 一月 200822 一月 2008

出版系列

名字Progress in Biomedical Optics and Imaging - Proceedings of SPIE
6860
ISSN(列印)1605-7422

Conference

ConferenceMultiphoton Microscopy in the Biomedical Sciences VIII
國家United States
城市San Jose, CA
期間20/01/0822/01/08

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