Cascade Synthesis of Benzimidazole-Linked Pyrroles via Copper Catalyzed Oxidative Cyclization and Ketonization

Tzuen Yang Ye, Manikandan Selvaraju, Chung-Ming Sun*

*Corresponding author for this work

研究成果: Article

11 引文 斯高帕斯(Scopus)

摘要

A three-component cascade reaction of 2-aminobenzimidazole, aldehyde, and terminal alkyne has been explored for an efficient synthesis of benzimidazole-linked tetrasubstituted pyrroles. The reaction sequence involves the formation of propargylamine, insertion of a terminal alkyne, and a ring opening reaction followed by an intramolecular carbonylative cyclization under aerobic conditions. It represents a novel strategy to the construction of C=N, C=C, C=O bonds and a new five-membered 2-ketopyrrole ring. In this process, the reaction conditions are crucial and an attempt to elucidate the novel reaction pathway is well supported by X-ray crystallography.

原文English
頁(從 - 到)3103-3106
頁數4
期刊Organic Letters
19
發行號12
DOIs
出版狀態Published - 16 六月 2017

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