Carboxylate-functionalized iron oxide nanoparticles in surface-assisted laser desorption/ionization mass spectrometry for the analysis of small biomolecules

Yu Chih Chiu, Yu-Chie Chen*

*Corresponding author for this work

研究成果: Article同行評審

12 引文 斯高帕斯(Scopus)

摘要

Iron oxide particles have been demonstrated previously as an effective SALDI-assisted material in SALDI MS analysis. The addition of a proton source such as citrate salts is helpful for rendering ionization efficiency. To simplify the sample preparation steps, we immobilize polyacrylic acid (PAA) onto the surface of the iron oxide particles. The modified iron oxide particles can be used as the SALDI-assisted material without the addition of extra proton source. Small biomolecules including bradykinin, melittin, and insulin are used to examine the feasibility of this approach. The results show that the SALDI mass spectral results are improved by using polyacrylic acid (MWaverage= ∼2 kDa) coated iron oxide nanoparticles.

原文English
頁(從 - 到)260-267
頁數8
期刊Analytical Letters
41
發行號2
DOIs
出版狀態Published - 1 一月 2008

指紋 深入研究「Carboxylate-functionalized iron oxide nanoparticles in surface-assisted laser desorption/ionization mass spectrometry for the analysis of small biomolecules」主題。共同形成了獨特的指紋。

引用此