Biothiol-triggered, self-disassembled silica nanobeads for intracellular drug delivery

Xin Chun Huang, Li Bang Wu, Jen Fang Hsu, Shinsuke Shigeto, Hsin-Yun Hsu*

*Corresponding author for this work

研究成果: Article

11 引文 斯高帕斯(Scopus)

摘要

Silica-based nanomaterials have demonstrated great potential in biomedical applications due to their chemical inertness. However, the degradability and endosomal trapping issues remain as rate-limiting barriers during their innovation. In this study, we provide a simple yet novel sol-gel approach to construct the redox-responsive silica nanobeads (ReSiNs), which could be rapidly disassembled upon redox gradient for intracellular drug delivery. The disulfide-linked scaffold of the nanobead was synthesized by employing the dithiobis-(succinimidyl propionate) to bridge (3-aminopropyl)-trimethoxysilane. Such silica matrix could be efficiently disrupted in response to intracellular glutathione, resulting in drug release and collapse of entire nanocarrier. Moreover, the ReSiNs exhibited insignificant cytotoxicity before and after the degradation. These results indicated the potential of using ReSiNs as a novel silica-based, biothiol-degradable nanoplatform for future drug delivery.

原文English
頁(從 - 到)263-270
頁數8
期刊Acta Biomaterialia
23
DOIs
出版狀態Published - 1 九月 2015

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