Alkyne carbonylation by radicals: Tin-radical-catalyzed synthesis of α-methylene amides from 1-alkynes, carbon monoxide, and amines

Yoshitaka Uenoyama*, Takahide Fukuyama, Osamu Nobuta, Hiroshi Matsubara, Ilhyong Ryu

*Corresponding author for this work

研究成果: Article同行評審

118 引文 斯高帕斯(Scopus)

摘要

A convergent synthesis of α-methylene amides exploits a hybrid radical/ionic concept in which radical carbonylation of alkynes is followed by ionic trapping of the resulting carbonyl-containing radical species with amines (see scheme). The reaction of substituted terminal alkynes with pressurized CO, Bu3SnH, and 2,2′-azobis-isobutyronitrile in the presence of a large excess of amines gave good yields of the corresponding α-methylene amides.

原文English
頁(從 - 到)1075-1078
頁數4
期刊Angewandte Chemie - International Edition
44
發行號7
DOIs
出版狀態Published - 4 二月 2005

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