A potential role for Helicobacter pylori heat shock protein 60 in gastric tumorigenesis

Chen Si Lin, Pei Juin He, Nu Man Tsai, Chi Han Li, Shang Chih Yang, Wei Tung Hsu, Ming Shiang Wu, Chang Jer Wu, Tain Lu Cheng, Kuang-Wen Liao*

*Corresponding author for this work

研究成果: Article同行評審

23 引文 斯高帕斯(Scopus)

摘要

Helicobacter pylori has been found to promote the malignant process leading to gastric cancer. Heat shock protein 60 of H. pylori (HpHSP60) was previously been identified as a potent immunogene. This study investigates the role of HpHSP60 in gastric cancer carcinogenesis. The effect of HpHSP60 on cell proliferation, anti-death activity, angiogenesis and cell migration were explored. The results showed that HpHSP60 enhanced migration by gastric cancer cells and promoted tube formation by umbilical vein endothelial cells (HUVECs); however, HpHSP60 did not increase cell proliferation nor was this protein able to rescue gastric cancer cells from death. Moreover, the results also indicated HpHSP60 had different effects on AGS gastric cancer cells or THP-1 monocytic cells in terms of their expression of pro-inflammatory cytokines, which are known to be important to cancer development. We propose that HpHSP60 may trigger the initiation of carcinogenesis by inducing pro-inflammatory cytokine release and by promoting angiogenesis and metastasis. Thus, this extracellular pathogen-derived HSP60 is potentially a vigorous virulence factor that can act as a carcinogen during gastric tumorigenesis.

原文English
頁(從 - 到)183-189
頁數7
期刊Biochemical and Biophysical Research Communications
392
發行號2
DOIs
出版狀態Published - 5 二月 2010

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