A novel ultrahigh-resolution surface plasmon resonance biosensor with an Au nanocluster-embedded dielectric film

W. P. Hu, Shean-Jen Chen*, K. T. Huang, J. H. Hsu, W. Y. Chen, G. L. Chang, K. A. Lai

*Corresponding author for this work

研究成果: Article同行評審

69 引文 斯高帕斯(Scopus)

摘要

The detection performance of conventional surface plasmon resonance (SPR) biosensors is limited to a 1pg/mm2 surface coverage of biomolecules, and consequently, such sensors struggle to detect the interaction of small molecules in low concentrations. The present study is attempted to propose the use of a novel SPR biosensor with Au nanoclusters embedded in a dielectric film to achieve a 10-fold improvement in the resolution performance. A co-sputtering method utilizing a multi-target sputtering system is used to fabricate the present dielectric films (SiO2) with embedded Au nanoclusters. It is shown that the sensitivity of the developed SPR biosensor can be improved by adjusting the size and volume fraction of the embedded Au nanoclusters in order to control the surface plasmon effect. The present gas detection and DNA hybridization experimental results confirm that the proposed Au nanocluster-enhanced SPR biosensor provides the potential to achieve an ultrahigh-resolution detection performance of approximately 0.1pg/mm 2 surface coverage of biomolecules.

原文English
頁(從 - 到)1465-1471
頁數7
期刊Biosensors and Bioelectronics
19
發行號11
DOIs
出版狀態Published - 15 六月 2004

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