A combinatorial approach to reconstructing transcriptional regulatory networks

Ying Z. Hsu*, Yuh-Jyh Hu

*Corresponding author for this work

研究成果: Conference contribution

摘要

One of the major challenges in molecular biology is to understand the precise mechanism by which gene expression is regulated. Reconstruction of transcription networks is essential to modeling this mechanism. In this paper, we describe a novel approach for building transcription networks from transcription modules by combining expression profile correlations with probabilistic element assessment. To demonstrate its performance, we systematically tested it on 27 transcription modules and reconstructed the transcription network for 6 transcription factors and 15 genes involved in the yeast cell cycle. The experimental results show that our combinatorial approach can better filter false positives to increase the selectivity in prediction of target genes. The regulatory control relationships described by the network reconstructed also mostly agree with those in earlier studies.

原文English
主出版物標題Proceedings of the International Conference on Mathematics and Engineering Techniques in Medicine and Biological Sciences, METMBS'04
編輯F. Valafar, H. Valafar
頁面352-358
頁數7
出版狀態Published - 1 十二月 2004
事件Proceedings of the International Conference on Mathematics and Engineering Techniques in medicine and Biological Sciences, METMBS'04 - Las Vegas, NV, United States
持續時間: 21 六月 200424 六月 2004

出版系列

名字Proceedings of the International Conference on Mathematics and Engineering Techniques in Medicine and Biological Sciences, METMBS'04

Conference

ConferenceProceedings of the International Conference on Mathematics and Engineering Techniques in medicine and Biological Sciences, METMBS'04
國家United States
城市Las Vegas, NV
期間21/06/0424/06/04

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