A prospective, cross-sectional study was conducted at a medical center in central Taiwan to understand the prevalence, associated factors, and microbiologic features for oropharyngeal yeast colonization in human immunodeficiency virus-infected outpatients. Oral yeast colonization was detected in 127 (45 %) patients, including 21 (16.5 %) colonized by more than one species. Of the 154 isolates, Candida albicans was the most common species (114, 74 %), followed by Candida dubliniensis (10, 6.5 %), Candida glabrata (10, 6.5 %), Candida tropicalis (7, 4.5 %), and 13 others. We found that receiving antituberculous drug (p = 0.046) or atazanavir (p = 0.045) was two predictors for patients colonized by non-C. albicans species (p = 0.005) and risking mixed yeast colonization (p = 0.009). Even though our data showed that clinical antifungal drugs remained effective in vitro against the colonizing yeasts, the increased mixed yeast colonization indicates a potential issue for controlling mixed infections in hospital settings.
- Human immunodeficiency virus; HIV; Colonization; Mixed yeast
- AMPHOTERICIN-B; MOLECULAR EPIDEMIOLOGY; CANDIDA-DUBLINIENSIS; PREDISPOSING FACTORS; ORAL CANDIDIASIS; CARRIAGE; FLUCONAZOLE; OUTPATIENTS; THERAPY; SUSCEPTIBILITIES
Ho, M-W., Yang, Y-L., Lin, C. C., Chi, C-Y., Chen, H-T., Lin, P-C., Hsieh, L-Y., Chou, C-H., Chu, W-L., Lauderdale, T-L., & Lo, H. J. (2014). Yeast Oropharyngeal Colonization in Human Immunodeficiency Virus-Infected Patients in Central Taiwan. Mycopathologia, 177(5-6), 309-317. https://doi.org/10.1007/s11046-014-9753-5