Yeast Oropharyngeal Colonization in Human Immunodeficiency Virus-Infected Patients in Central Taiwan

Mao-Wang Ho, Yun-Liang Yang, Chao Chih Lin, Chih-Yu Chi, Hui-Ting Chen, Po-Chang Lin, Li-Yun Hsieh, Chia-Hui Chou, Wen-Li Chu, Tsai-Ling Lauderdale, Hsiu Jung Lo

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Abstract

A prospective, cross-sectional study was conducted at a medical center in central Taiwan to understand the prevalence, associated factors, and microbiologic features for oropharyngeal yeast colonization in human immunodeficiency virus-infected outpatients. Oral yeast colonization was detected in 127 (45 %) patients, including 21 (16.5 %) colonized by more than one species. Of the 154 isolates, Candida albicans was the most common species (114, 74 %), followed by Candida dubliniensis (10, 6.5 %), Candida glabrata (10, 6.5 %), Candida tropicalis (7, 4.5 %), and 13 others. We found that receiving antituberculous drug (p = 0.046) or atazanavir (p = 0.045) was two predictors for patients colonized by non-C. albicans species (p = 0.005) and risking mixed yeast colonization (p = 0.009). Even though our data showed that clinical antifungal drugs remained effective in vitro against the colonizing yeasts, the increased mixed yeast colonization indicates a potential issue for controlling mixed infections in hospital settings.
Original languageEnglish
Pages (from-to)309-317
Number of pages9
JournalMycopathologia
Volume177
Issue number5-6
DOIs
StatePublished - Jun 2014

Keywords

  • Human immunodeficiency virus; HIV; Colonization; Mixed yeast
  • AMPHOTERICIN-B; MOLECULAR EPIDEMIOLOGY; CANDIDA-DUBLINIENSIS; PREDISPOSING FACTORS; ORAL CANDIDIASIS; CARRIAGE; FLUCONAZOLE; OUTPATIENTS; THERAPY; SUSCEPTIBILITIES

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    Ho, M-W., Yang, Y-L., Lin, C. C., Chi, C-Y., Chen, H-T., Lin, P-C., Hsieh, L-Y., Chou, C-H., Chu, W-L., Lauderdale, T-L., & Lo, H. J. (2014). Yeast Oropharyngeal Colonization in Human Immunodeficiency Virus-Infected Patients in Central Taiwan. Mycopathologia, 177(5-6), 309-317. https://doi.org/10.1007/s11046-014-9753-5