X-ray microscopy and tomography detect the accumulation of bare and PEG-coated gold nanoparticles in normal and tumor mouse tissues

C. C. Chien, Chang-Chieh Cheng, H. H. Chen, Y. Hwu*, Y. S. Chu, C. Petibois, A. Chen, Yu-Tai Ching, G. Margaritondo

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

We demonstrate that, with appropriate staining, high-resolution X-ray microscopy can image complicated tissue structures-cerebellum and liver-and resolve large or small amounts of Au nanoparticles in these tissues. Specifically, images of tumor tissue reveal high concentrations of accumulated Au nanoparticles. PEG (poly(ethylene glycol)) coating is quite effective in enhancing this accumulation and significantly modifies the mechanism of uptake by reticuloendothelial system (RES) organs.

Original languageEnglish
Pages (from-to)1287-1296
Number of pages10
JournalAnalytical and Bioanalytical Chemistry
Volume404
Issue number5
DOIs
StatePublished - 1 Sep 2012

Keywords

  • 3D tissue imaging
  • High resolution X-ray microscopy
  • Nanoparticles

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