What is the difference of cell deformation between push and pull?

Chia-Hung Tsai*, S. Sakuma, F. Arai, M. Kaneko

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

The difference of cell deformation passing through a microchannel by positive- and negative-pressure driven flow, which are defined as "PUSH" and "PULL" in this paper, is investigated based on the experimental results. While both cases are commonly utilized in microfluidic applications, the aim of this work is to point out the fundamental difference of them regarding cell deformation. Experiments are carried out by using osmotic-swollen RBCs for exaggerating the difference. Two observational parameters, maximum insertion length and cell membrane curvature, are obtained for each tested RBC. According to the results, the cell deformation under PUSH and PULL is statistically different.

Original languageEnglish
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages793-795
Number of pages3
ISBN (Electronic)9780979806476
StatePublished - 1 Jan 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: 26 Oct 201430 Oct 2014

Publication series

Name18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Conference

Conference18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period26/10/1430/10/14

Keywords

  • Cell deformability
  • Positive- and negative-pressure driven flow

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