Wave-vector-encoded nonlinear endomicroscopy

Guan Yu Zhuo, Po Lin Tsai, Hsien Yi Wang, Ming Che Chan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Based on a rigid square fiber for wave vector delivery, we present a novel (to the best of our knowledge) wave-vectorencoded nonlinear-optical endomicroscopy (WENE). WENE overcomes three tangled issues, including femtosecond pulse broadening induced signal degradation, complexity of packaging miniaturized scanners in the distal end, and pixel-like images, which cannot be fully addressed by current distal scanning nonlinear endomicroscopy (NE) or fiber-bundle-based proximal scanning NE. Due to the advantages of its simplicity in overall configuration and package in the distal end, the capability of addressing the issue of pulse broadening, and offering continuous wave vector delivery, the demonstrated WENE shows great promise for future basic research on biomedical processes and minimally invasive utilization for clinical diagnosis.

Original languageEnglish
Pages (from-to)3713-3716
Number of pages4
JournalOptics Letters
Issue number13
StatePublished - 1 Jul 2020

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