An experimental study was carried out to examine the vapor pressure of R-410A and R-407C in the presence of lubricant oil. The grades of the tested lubricants are ISO-32 and ISO-100. For R-410A refrigerant, the vapor pressure decreases with the increase of oil concentration. In addition, it is found that there are no significant changes of vapor pressures for the presence of lubricant oils for Ts≤25 °C. For R-407C refrigerant, the change of vapor pressure with oil concentration is comparatively small. It is likely that this phenomenon is related to the zeotropic nature of R-407C.