Uteroglobin: A novel cytokine?

A. B. Mukherjee*, G. C. Kundu, G. Mantile-Selvaggi, Chiun-Jye Yuan, A. K. Mandal, S. Chattopadhyay, F. Zheng, N. Pattabiraman, Z. Zhang

*Corresponding author for this work

Research output: Contribution to journalReview article

113 Scopus citations

Abstract

Blastokinin or uteroglobin (UG) is a steroid-inducible, evolutionarily conserved, multifunctional protein secreted by the mucosal epithelia of virtually all mammals. It is present in the blood and in other body fluids including urine. An antigen immunoreactive to UG antibody is also detectable in the mucosal epithelia of all vertebrates. UG-binding proteins (putative receptor), expressed on several normal and cancer cell types, have been characterized. The human UG gene is mapped to chromosome 11q12.2-13.1, a region that is frequently rearranged or deleted in many cancers. The generation of UG knockout mice revealed that disruption of this gene causes: (i) severe renal disease due to an abnormal deposition of fibronectin and collagen in the glomeruli; (ii) predisposition to a high incidence of malignancies; and (iii) a lack of polychlorinated biphenyl binding and increased oxygen toxicity in the lungs. The mechanism(s) of UG action is likely to be even more complex as it also functions via a putative receptor-mediated pathway that has not yet been clearly defined. Molecular characterization of the UG receptor and signal transduction via this receptor pathway may show that this protein belongs to a novel cytokine/chemokine family.

Original languageEnglish
Pages (from-to)771-787
Number of pages17
JournalCellular and Molecular Life Sciences
Volume55
Issue number5
DOIs
StatePublished - 14 Jun 1999

Keywords

  • Blastokinin
  • CC10
  • Cytokine
  • ECM
  • Fibronectin
  • PLA
  • Receptor
  • Uteroglobin

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    Mukherjee, A. B., Kundu, G. C., Mantile-Selvaggi, G., Yuan, C-J., Mandal, A. K., Chattopadhyay, S., Zheng, F., Pattabiraman, N., & Zhang, Z. (1999). Uteroglobin: A novel cytokine? Cellular and Molecular Life Sciences, 55(5), 771-787. https://doi.org/10.1007/s000180050331