Using Oxidized Low-Density Lipoprotein Autoantibodies to Predict Restenosis after Balloon Angioplasty in Patients with Acute Myocardial Infarction

Ching Hui Huang, Chia Chu Chang, Ching Shan Huang, Chen Ling Kuo, Ching Pei Chen, Chien Hsun Hsia, Yung Ming Chang, Hung Te Chen, Chih Chung Feng, Lee Shin Lin, Po Ta Yang, Chen Dao Tsai, Chih-Sheng Lin*, Chin San Liu

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Objectives:Oxidized low-density lipoproteins (oxLDL) and oxidized low-density lipoprotein autoantibodies (OLAB) have been detected in human plasma and atherosclerotic lesions. OLAB appear to play a role in the clearance of oxLDL from circulation. Higher levels of OLAB appear to be associated with a reduced risk of a wide range of cardiovascular diseases. We investigated the prognostic value of plasma oxLDL and OLAB in patients undergoing primary coronary balloon angioplasty for acute ST-elevation myocardial infarction (STEMI).Methods:Plasma oxLDL and OLAB concentrations were measured in 56 patients with acute STEMI before primary angioplasty, and then 3 days, 7 days and 1 month after the acute event. Follow-up angiography was repeated 6 months later to detect the presence of restensosis (defined as >50% luminal diameter stenosis). The thrombolysis in myocardial infarction (TIMI) risk score was calculated to determine the relationship between OLAB/oxLDL ratio and TIMI risk scores.Results:Of the 56 patients, 18 (31%) had angiographic evidence of restenosis. Plasma OLAB concentrations were significantly lower in the restenosis group before angioplasty (181±114 vs. 335±257 U/L, p = 0.003), and at day 3 (155±92 vs. 277±185 U/L, p<0.001) and day 7 (177±110 vs. 352±279 U/L, p<0.001) after the acute event. There was no difference in oxLDL concentration between the two groups. The ratio of OLAB/oxLDL positively correlated with TIMI risk scores before angioplasty (p for trend analysis, p = 0.004), at day 3 (p = 0.008) and day 7 (p<0.001) after STEMI.Significance:A relative deficit of OLAB, and hence likely impaired clearance of oxLDL, is associated with the risk of arterial restenosis after primary angioplasty for acute STEMI.

Original languageEnglish
Article numbere74726
JournalPLoS ONE
Volume8
Issue number10
DOIs
StatePublished - 3 Oct 2013

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    Huang, C. H., Chang, C. C., Huang, C. S., Kuo, C. L., Chen, C. P., Hsia, C. H., Chang, Y. M., Chen, H. T., Feng, C. C., Lin, L. S., Yang, P. T., Tsai, C. D., Lin, C-S., & Liu, C. S. (2013). Using Oxidized Low-Density Lipoprotein Autoantibodies to Predict Restenosis after Balloon Angioplasty in Patients with Acute Myocardial Infarction. PLoS ONE, 8(10), [e74726]. https://doi.org/10.1371/journal.pone.0074726