Using optical tweezers to examine the chemotactic force to a single inflammatory cell - Eosinophil stimulated by chemoattractants prepared from Toxocara Canis Iarvae

Po Chen Shih*, Yi Jr Su, Ke Min Chen, Lin Ni Jen, Cheng Tzu Liu, Long Hsu

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

Abstract

Granulocytes are a group of white blood cells belonging to the innate immune system in human and in murine in which eosinophils play an important role in worm infection-induced inflammation. The migration of these cells is well characterized and has been separated into four steps: rolling, adhesion, transendothelial migration, and chemotaxis, however, the physical characteristics of the chemotactic force to eosinophils from worm component remain largely unknown. Note that optical tweezers are featured in the manipulation of a single cell and the measurement of biological forces. Therefore, we propose to use optical tweezers to examine the chemotactic force to a eosinophil from a T. canis lavae preparation in terms of distance during the migration of eosinophil.

Original languageEnglish
Article number59301R
Pages (from-to)1-9
Number of pages9
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5930
DOIs
StatePublished - 1 Dec 2005
EventOptical Trapping and Optical Micromanipulation II - San Diego, CA, United States
Duration: 31 Jul 20054 Aug 2005

Keywords

  • Chemotacfic force
  • Eosinophil
  • Optical tweezers

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