Using a wearable near-infrared spectroscopy device in children with Tourette syndrome

Pou Leng Cheong, Ting Yi Li, Chia-Wei Sun

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

1. Background Tourette syndrome (TS) is a neurological disorder characterized by repetitive, stereotyped, involuntary movements and vocalizations called tics. Near-Infrared Spectroscopy (NIRS) can assess brain function non-invasively by detecting changes in blood hemoglobin concentrations associated with neural activity with tasks like Posner's paradigm (concerning response inhibition and attention shifts). 2. Objective To develop a possible noninvasive objective neuroimaging protocol with a wearable wireless device for assessment of brain activities in children with Tourette syndrome. 3. Method Children aged 6-15 years, with TS or healthy control, received functional NIRS (task-based) with the Posner paradigm after informed consent and neuropsychiatric tests (including WISC-IV test, SNAP-IV rating scale, Yale Global Tic Severity Scale Score). Behavioral data (reaction time and error rates (omission, anticipation, orientation) and NIRS data for neural changes by changes in oxy-hemoglobin and deoxy-hemoglobin levels were recorded and statistically analyzed using the SPSS software. 4. Results 20 subjects were included, 13 male and 7 female (mean age: 9.79 years; all right-handed). No significant differences in reaction time and error rate between Tourette subjects and control. For the NIRS data, more dominant activation at left prefrontal area with increasing flow with task was seen in control subjects while no dominant activation or flow increase with task was noted in Tourette subjects. 5. Conclusion NIRS with prefrontal channels with the wearable wireless device can effectively assess the frontal activation differences and thus probably act as promising neurofeedback tools for TS or other developmental disorders like autism or attention deficit hyperactivity disorder.

Original languageEnglish
Title of host publicationDiagnosis and Treatment of Diseases in the Breast and Reproductive System IV
EditorsMelissa C. Skala, Paul J. Campagnola
PublisherSPIE
ISBN (Electronic)9781510614291
DOIs
StatePublished - 1 Jan 2018
EventDiagnosis and Treatment of Diseases in the Breast and Reproductive System IV 2018 - San Francisco, United States
Duration: 27 Jan 201828 Jan 2018

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10472
ISSN (Print)1605-7422

Conference

ConferenceDiagnosis and Treatment of Diseases in the Breast and Reproductive System IV 2018
CountryUnited States
CitySan Francisco
Period27/01/1828/01/18

Keywords

  • Posner paradigm
  • Tourette syndrome
  • near-infrared spectroscopy

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