Ultrasound ionization of biomolecules

Chen I. Wu, Yi Sheng Wang, G. Chen, Chung Yi Wu, Chung Hsuan Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

To date, mass spectrometric analysis of biomolecules has been primarily performed with either matrix-assisted laser desorption/ionization (MALDI) or electrospray ionization (ESI). In this work, ultrasound produced by a simple piezoelectric device is shown as an alternative method for soft ionization of biomolecules. Precursor ions of proteins, saccharides and fatty acids showed little fragmentation. Cavitation is considered as a primary mechanism for the ionization of biomolecules.

Original languageEnglish
Pages (from-to)2569-2574
Number of pages6
JournalRapid Communications in Mass Spectrometry
Volume24
Issue number17
DOIs
StatePublished - 15 Sep 2010

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