Ultrafast plane wave imaging based pulsed magnetomotive ultrasound

Pei Hsien Ting, Yi Da Kang, San-Yuan Chen, Meng Lin Li*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Recently, pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect magnetic nanoparticles (MNPs) which are not able to be visualized by conventional ultrasound. However, because of the used magnetic short pulse, the reported pMMUS only can use a single-element ultrasound transducer along with mechanical scanning to perform imaging, which significantly limits the imaging fame rate. To solve this problem, we propose an ultrafast plane wave imaging based pMMUS technique. The ultrafast frame rate of plane wave imaging is fast enough to track the magneto-motion of the excited MNPs during the period of the magnetic pulse being applied. Therefore, the proposed ultrafast plane wave pMMUS is capable of visualizing the dynamic response of the excited MNPs, which is highly correlated to tissue characteristics, to an externally-applied magnetic pulse. In our experiments, ultrafast plane wave imaging with a 5 kHz frame rate was used to implement the pMMUS where the MNP motion induced by an 8-ms magnetic pulse was tracked. The results showed that there were significant differences between the ultrafast plane wave pMMUS images of the phantoms with and without MNPs embedded. In addition, gelatin phantoms with 2%, 4% and 6% gelatin were used to mimic tissues with different elasticity. The dynamic responses of the excited MNPs in the three types of phantoms were distinguishable. Overall, it is demonstrated that the feasibility of our proposed ultrafast plane wave pMMUS imaging technique for the visualization of the magneto-motion and dynamic response of the MNPs under the excitation of a short magnetic pulse. More studies are required to further improve the magneto-motion tracking algorithm and explore the relationship between the dynamic response of the excited MNPs and the tissue viscosity and elasticity.

Original languageEnglish
Title of host publicationIEEE International Ultrasonics Symposium, IUS
PublisherIEEE Computer Society
Pages456-458
Number of pages3
ISBN (Electronic)9781479970490
DOIs
StatePublished - 20 Oct 2014
Event2014 IEEE International Ultrasonics Symposium, IUS 2014 - Chicago, United States
Duration: 3 Sep 20146 Sep 2014

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

Conference2014 IEEE International Ultrasonics Symposium, IUS 2014
CountryUnited States
CityChicago
Period3/09/146/09/14

Keywords

  • magnetic nanoparticles
  • magnetomotive ultrasound
  • plane wave imaging

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