In the 21th century, university is a knowledge factory for teachers and scholars to perform education and research, and a translation media of science to technology. Universities are emerged to transform that is directed by repositioning after evaluation. University policy makers are missioned to reposition their universities for the 21th century market. Foreseeing transformation from education/research to entrepreneurial due to market demand, policy makers are suggested to adopt Mintzberg's strategic planning principle for repositioning, CIPP and BSC models for internal evaluation, SWOT and Porter's 5 force analysis for internal and external evaluation to relocate the positions of universities. The indicators for self- and internal evaluation and repositioning may follow CUAA and Californian systems. A SMTIE model for university positioning is proposed. Using Taiwan as a local case study, it is suggested that public universities would to be merged to 'multiversity' and private universities would transform to 'entrepreneurial' or becoming 'omniversity' according to the evaluation based on SMITE model.