Transfer function of macro-micro manipulation on a PDMS microfluidic chip

Koji Mizoue, Kaoru Teramura, Chia-Hung Tsai*, Makoto Kaneko

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


To achieve fast and accurate cell manipulation in a microfluidic channel, it is essential to know the true nature of its input-output relationship. This paper aims to reveal the transfer function of such a micro manipulation controlled by a macro actuator. Both a theoretical model and experimental results for the manipulation are presented. A second-order transfer function is derived based on the proposed model, where the polydimethylsiloxane (PDMS) deformation plays an important role in the manipulation. Experiments are conducted with input frequencies up to 300 Hz. An interesting observation from the experimental results is that the frequency responses of the transfer function behave just like a first-order integration operator in the system. The role of PDMS deformation for the transfer function is discussed based on the experimentally-determined parameters and the proposed model.

Original languageEnglish
Article number80
Issue number3
StatePublished - 1 Jan 2017


  • Cell manipulation
  • Macro actuator
  • Microfluidic channel
  • Transfer function

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