Traceless synthesis of hydantoin fused tetrahydro-β-carboline on ionic liquid support in green media

Barnali Maiti*, Kaushik Chanda, Chung-Ming Sun

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

A novel Ionic liquid (IL) supported, green synthetic protocol has been developed toward the synthesis of oxo and thio hydantoin analogues tethered with tetrahydro-β-carboline by the use of focused microwave irradiation. IL-bound tryptophan underwent a Pictet-Spengler reaction with various carbonyl compounds to generate the IL- immobilized tetrahydro-β-carbolines in aqueous isopropanol media. Subsequent reaction of substituted tetrahydro-β-carboline derivatives with various isocyanates and isothiocyanate provided a three-dimensional combinatorial library in a traceless fashion.

Original languageEnglish
Pages (from-to)4826-4829
Number of pages4
JournalOrganic Letters
Volume11
Issue number21
DOIs
StatePublished - 5 Nov 2009

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