Traceless synthesis of hydantoin by focused microwave irradiation

Ming Juan Lee, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticle

49 Scopus citations


An efficient, microwave-assisted method for the liquid-phase combinatorial synthesis of 1,3-disubstituted hydantoin has been developed. Chloroacetyl chloride was directly anchored to HO-PEG-OH and subsequently reacted with various primary amines in a microwave cavity. The PEG bound secondary amine coupled with isocyanates and concomitant cyclization-cleavage step occurred in mild basic conditions by microwave flash heating. The desired products were then liberated from the soluble matrix in modest yield and high purity.

Original languageEnglish
Pages (from-to)437-440
Number of pages4
JournalTetrahedron Letters
Issue number2
StatePublished - 5 Jan 2004


  • Combinatorial chemistry
  • Hydantoin
  • Microwave irradiation
  • Traceless synthesis

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